NAC (N-Acetylcysteine) Dose Calculator
If body weight > 110 kg, use 110 kg
⚠️ Weight exceeds 110 kg. Please use 110 kg for calculation.
⚠️ Important Note
IV NAC should ONLY BE USED for Paracetamol Poisoning in paediatric patients.
Results
Summary of Input
Recommended Regimen
Calculated NAC Dose based on Weight
Total NAC Dose
Vials Needed (5g/25mL)
📋 Clinical Notes Template
💊 Nurse Preparation & Administration Guide
📌 Important Information
Diluents: D5 (more preferred) or NS
Stability: 24 hrs after dilution (<30°C)
🔗 NAC 5g/25mL Inj Newsletter by PRIC HSgB (Updated July 2024)
📚 Quick Reference: When to Use Each Regimen
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Paracetamol Poisoning
- 2 bags infusion (preferred): Standard protocol for most cases
- 3 bags infusion: Alternative regimen
Non-Paracetamol Acute Liver Failure (Adults Only)
- ICU / Fluid Restricted: Undiluted NAC for critical patients or patients requiring fluid restriction
- Non-ICU / No Fluid Restriction: Diluted NAC for stable patients
🔬 NAC Mechanism of Action (MOA) in PCM Poisoning
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NAC is a glutathione precursor that decreases PCM toxicity by increasing hepatic glutathione stores.
It helps prevent hepatic toxicity by inactivating the toxic PCM metabolite NAPQI before it can injure liver cells.
However, it does not reverse damage to liver cells that have already occurred.